Mechanism of Action
SARMS Aicar powder’s principal mechanism of action is activation of AMPK (AMP-activated protein kinase.) As is well known, ATP (adenosine triphosphate) is produced by mitochondria as a ready-to-use energy source for biochemical processes in the cell. These processes do not use glucose, fats, or fatty acids directly as energy sources: these must first be metabolized in the mitochondria to yield ATP. When ATP is used for energy, its first product is ADP (adenosine di-phosphate), and then – if the cell is really deprived of immediate sources of energy – finally to AMP (adenosine monophosphate.)
SARMS Aicar powder, at sufficient and quite substantial concentration, is effective at activating AMPK and inducing a cellular state as if exercise had been performed, or energy stores were low and fat therefore needed to be burned.
Reputedly typical dosage has been about 500 mg/day for about four weeks prior to an event. This is lower than human-equivalent from animal research studies, but not so much so as to strain credulity. (In contrast, for example only 50 mg per day instead of 500 mg absolutely does strain credulity, let alone the 10 mg doses used by some as part of their stacks.)
In general I would recommend against using AICAR, but if wishing to do so anyway, I would use 500 mg/day for a limited period of time such as 4 weeks. For almost all persons this would be financially impractical with 50 mg pre-prepared vials.